Cláudia Funchal Selected Research

alpha-keto-beta-methylvaleric acid (KMVA)

9/2007	Effect of the branched-chain alpha-keto acids accumulating in maple syrup urine disease on S100B release from glial cells.
2/2006	Creatine and antioxidant treatment prevent the inhibition of creatine kinase activity and the morphological alterations of C6 glioma cells induced by the branched-chain alpha-keto acids accumulating in maple syrup urine disease.

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Cláudia Funchal Research Topics

Disease

12	Maple Syrup Urine Disease 09/2007 - 12/2002
7	Glioma (Gliomas) 11/2007 - 02/2006
5	Body Weight (Weight, Body) 01/2022 - 12/2011
4	Decapitation 09/2015 - 06/2012
3	Tyrosinemias (Tyrosinemia) 01/2015 - 09/2011
2	Propionic Acidemia 03/2006 - 09/2003
1	Type C Niemann-Pick Disease (Niemann Pick Disease, Type C) 10/2015
1	Hepatic Encephalopathy 01/2015
1	Glutaric Acidemia I 01/2007
1	Neoplasms (Cancer) 09/2006
1	Methylmalonic acidemia 09/2003

Drug/Important Bio-Agent (IBA)

6	Keto AcidsIBA 09/2007 - 04/2004
5	alpha-ketoisocaproic acidIBA 09/2007 - 12/2002
4	AntioxidantsIBA 04/2014 - 02/2006
4	Amino Acids FDA Link 09/2007 - 08/2005
4	Proteins (Proteins, Gene)FDA Link 11/2005 - 12/2002
4	AcidsIBA 09/2005 - 12/2002
3	Tyrosine (L-Tyrosine)FDA Link 01/2015 - 09/2011
3	EnzymesIBA 01/2015 - 02/2006
3	CreatineIBA 05/2012 - 02/2006
3	Biological ProductsIBA 09/2007 - 02/2006
2	Alanine (L-Alanine)FDA Link 06/2018 - 08/2013
2	Saline SolutionIBA 06/2018 - 08/2013
2	CholesterolIBA 10/2015 - 06/2012
2	Creatine Kinase (Creatine Phosphokinase)IBA 09/2011 - 02/2006
2	Glial Fibrillary Acidic ProteinIBA 11/2007 - 09/2005
2	alpha-ketoisovalerateIBA 09/2007 - 02/2006
2	alpha-keto-beta-methylvaleric acid (KMVA)IBA 09/2007 - 02/2006
2	ResveratrolIBA 07/2007 - 09/2006
2	Glutamic Acid (Glutamate)FDA Link 09/2006 - 04/2004
1	Indomethacin (Indometacin)FDA LinkGeneric 01/2022
1	3- beta- (2- (diethylamino)ethoxy)androst- 5- en- 17- oneIBA 10/2015
1	InterleukinsIBA 09/2015
1	Interleukin-18 (Interleukin 18)IBA 09/2015
1	Interleukin-10 (Interleukin 10)IBA 09/2015
1	Interleukin-6 (Interleukin 6)IBA 09/2015
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 09/2015
1	Neuroprotective AgentsIBA 01/2015
1	IceIBA 11/2013
1	Triglycerides (Triacylglycerol)IBA 06/2012
1	Alanine Transaminase (SGPT)IBA 06/2012
1	Aspartate Aminotransferases (Aspartate Transaminase)IBA 06/2012
1	C-Reactive ProteinIBA 06/2012
1	CreatinineIBA 06/2012
1	Glucose (Dextrose)FDA LinkGeneric 06/2012
1	Hemoglobins (Hemoglobin)IBA 06/2012
1	L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA 06/2012
1	Urea (Carbamide)FDA LinkGeneric 06/2012
1	Tyrosine Transaminase (Tyrosine Aminotransferase)IBA 05/2012
1	tyrosine methyl esterIBA 05/2012
1	Pharmaceutical PreparationsIBA 12/2011
1	Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric 07/2007
1	Isoleucine (L-Isoleucine)FDA Link 05/2007
1	Leucine (L-Leucine)FDA Link 05/2007
1	Valine (L-Valine)FDA Link 05/2007
1	Branched-Chain Amino AcidsIBA 05/2007
1	anthranilic acid (anthranilate)IBA 01/2007
1	Free RadicalsIBA 01/2007
1	3-hydroxykynurenineIBA 01/2007
1	3-Hydroxyanthranilic AcidIBA 01/2007
1	KynurenineIBA 01/2007
1	glutaric acidIBA 01/2007
1	Superoxide DismutaseIBA 12/2006
1	CatalaseIBA 12/2006
1	Glutathione PeroxidaseIBA 12/2006
1	Glutathione (Reduced Glutathione)IBA 12/2006
1	Nitric Oxide (Nitrogen Monoxide)FDA Link 12/2006
1	CytokinesIBA 09/2006
1	Glutamate-Ammonia Ligase (Glutamine Synthetase)IBA 09/2006
1	VimentinIBA 03/2006
1	Cytoskeletal ProteinsIBA 09/2005
1	N-Methylaspartate (NMDA)IBA 09/2005
1	Intermediate Filament ProteinsIBA 09/2003
1	PropionatesIBA 09/2003

Therapy/Procedure

2	Injections 06/2018 - 08/2013